Article Correctness Is Author's Responsibility: Genes, stress and childhood adversity: Impact on risky drinking and drug-use

Exposure to adversity as a child can affect how the body responds to stress, and may increase the risk of negative health behaviors and addictions in adulthood. However, the impact of early life adversity may depend partly on an individual's genetic makeup. The 'COMT' gene is of particular interest ─ it occurs in two common variant forms, MET and VAL, that differentially affect key molecules involved in the human stress response, and these gene variants may also influence vulnerability to our early environment.