Article Correctness Is Author's Responsibility: How the enzyme lipoxygenase drives heart failure after heart attacks

(University of Alabama at Birmingham) Heart failure after a heart attack is a global epidemic leading to heart failure pathology. Ganesh Halade, Ph.D., is seeking ways to delay or reverse this heart failure, which comes from non-resolved chronic inflammation. In a study in Metabolism: Clinical and Experimental, Halade and colleagues detail the profound lipidomic and metabolic signatures and the modified leukocyte profiling that delay heart failure progression and provide improved survival in 12/15 lipoxygenase-deficient mice.