Article Correctness Is Author's Responsibility: Molecular basis of brain dysfunction and embryo malformation associated with thalidomide

Scientists have identified the molecule involved in thalidomide-related dysfunctions associated with in utero brain and organ development. Their in vivo results using a zebrafish model of mammalian development showed that thalidomide binds to a protein named cereblon, a subunit of an enzyme complex responsible for the creation of neurons, thereby inhibiting normal brain development. Their results suggest this protein as a possible therapeutic target for regulating abnormal brain development.