Article Correctness Is Author's Responsibility: A Virus, a Gene and a Pill Used to Harness the Immune System to Fight Brain Tumor in Children

Newswise imageThe first patient in a new Phase 1 gene therapy trial for pediatric brain tumors underwent a leading-edge procedure at Ann & Robert H. Lurie Children's Hospital of Chicago. During surgery to remove the brain tumor, the patient was injected with an adenovirus, a common cold virus, at the tumor site. The virus was bioengineered not to cause illness but rather deliver a gene that produces human interleukin 12 (hIL-12), a powerful protein to jumpstart the immune system to kill remaining tumor cells. For the next 14 days, the patient is given a pill - veledimex - to activate the gene and control the immune response, so that the inflammation fights the tumor without overwhelming the rest of the body.